研究成果

研究成果(2012年)

中間評価資料(2012年6月作製)

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研究成果(2010年)

Kikushige Y, Shima T, Takayanagi SI, Urata S, Miyamoto T, Iwasaki H, Takenaka K, Teshima T, Tanaka T, Inagaki Y, Akashi K. TIM-3 is a promising target to selectively kill acute myeloid leukemia stem cells. Cell Stem Cell, in press.

Oku S, Takenaka K, Kuriyama T, Shide K, Kumano T, Kikushige Y, Urata S, Yamauchi T, Iwamoto C, Shimoda HK, Miyamoto T, Nagafuji K, Kishimoto J, Shimoda K, Akashi K. JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation. Br J Haematol, 150(3): 334-344, 2010

Asakura S, Hashimoto D, Takashima S, Sugiyama H, Maeda Y, Akashi K, Tanimoto M, Teshima T. Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice. J Clin Invest, 120(7): 2370-2378, 2010.

Hirano G, Izumi H, Kidani A, Yasuniwa Y, Han B, Kusaba H, Akashi K, Kuwano M, Kohno K. Enhanced expression of PCAF endows apoptosis resistance in cisplatin-resistant cells. Mol Cancer Res, 8(6): 864-872, 2010.

Parmar K, Kim J, Sykes SM, Shimamura A, Stuckert P, Zhu K, Hamilton A, Deloach MK, Kutok JL, Akashi K, Gilliland DG, D'andrea A. Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1. Stem Cells, 28(7): 1186-1195, 2010.

Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S. Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. Blood, 115(14): 2872-2881, 2010.

Wang H, Bauzon F, Ji P, Xu X, Sun D, Locker J, Sellers RS, Nakayama K, Nakayama KI, Cobrinik D, Zhu L. Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/- mice. Nature Genet, 42: 83-88, 2010.

Tsukada Y, Ishitani T, Nakayama KI. KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development. Genes Dev, 24: 432-437, 2010.

Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK. Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis. Nature Cell Biol, 12: 457-467, 2010.

Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature, 464: 374-379, 2010.

Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama KI. Fbxw7 controls lipid metabolism and cell fate decision in the liver in mice. J Clin Invest, in press.

Takeda H, Kawamura Y, Miura A, Mori M, Wakamatsu A, Yamamoto JI, Isogai T, Matsumoto M, Nakayama KI, Natsume T, Nomura N, Goshima N. Comparative Analysis of Human Src-family Kinase Substrate Specificity in vitro. J Proteome Res, in press.

Tsukada Y, Nakayama KI. In vitro histone demethylase assay. Cold Spring Harb Protoc, in press.

Benirschke RC, Thompson JR, Nomine Y, Wasielewski E, Juranic N, Macura S, Hatakeyama S, Nakayama KI, Botuyan MV, Mer G. Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4. Structure, 18: 955-965, 2010.

Ma H, Yu L, Byra EA, Hu N, Kitagawa K, Nakayama KI, Kawamoto T, Ren J. Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases. J Mol Cell Cardiol, 49: 322-329, 2010.

Okumura F, Matsunaga Y, Katayama Y, Nakayama KI, Hatakeyama S. TRIM8 modulates STAT3 activity through negative regulation of PIAS3. J Cell Sci, 123: 2238-2245, 2010.

Mizokami A, Tanaka H, Ishibashi H, Umebayashi H, Fukami K, Takenawa T, Nakayama KI, Yokoyama T, Nabekura J, Kanematsu T, Hirata M. GABA(A) receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice. J Neurochem, 114: 302-310, 2010.

Hatano A, Matsumoto M, Higashinakagawa T, Nakayama KI. Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3. Biochem Biophys Res Commun, 397: 93-99, 2010.

Ohzono C, Etoh S, Matsumoto M, Nakayama KI, Hirota Y, Tanaka Y, Fujita H. Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43. Biol Pharm Bull, 33: 951-957, 2010.

Susaki E, Kaneko-Oshikawa C, Miyata K, Tabata M, Yamada T, Oike Y, Katagiri H, Nakayama KI. Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity. J Biol Chem, 285: 15538-15547, 2010.

Iwatsuki M, Mimori K, Ishii H, Yokobori T, Takatsuno Y, Sato T, Toh H, Onoyama I, Nakayama KI, Baba H, Mori M. Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: clinical significance. Int J Cancer, 126: 1828-1837, 2010.

Masuda K, Ishikawa Y, Onoyama I, Unno M, de Alboran IM, Nakayama KI, Nakayama K. Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts. Oncogene, 29: 1798-1809, 2010.

Old JB, Kratzat S, Hoellein A, Graf S, Nilsson JA, Nilsson L, Nakayama KI, Peschel C, Cleveland JL, Keller UB. Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis. Mol Cancer Res, 8: 353-362, 2010.

Fujii M, Kanematsu T, Ishibashi H, Fukami K, Takenawa T, Nakayama KI, Moss SJ, Nabekura J, Hirata M. Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of gamma-aminobutyric acid type A receptors. J Biol Chem, 285: 4837-4846, 2010.

Tada H, Okano HJ, Takagi H, Shibata S, Yao I, Matsumoto M, Saiga T, Nakayama KI, Kashima H, Takahashi T, Setou M, Okano H. Fbxo45, a novel ubiquitin ligase, regulates synaptic activity. J Biol Chem, 285: 3840-3849, 2010.

Tanaka S, Wakeyama H, Akiyama T, Takahashi K, Amano H, Nakayama KI, Nakamura K. Regulation of osteoclast apoptosis by bcl-2 family protein bim and caspase-3. Adv Exp Med Biol, 658: 111-116, 2010.

Iwasaki H, Suda T: Hematopoietic Stem Cells and Their Niche. In:Motonari Kondo ed., Hematopoietic Stem Cell Biology, New York, Humana Press, 37-55, 2010.

Kobayashi I, Ono H, Moritomo T, Kano K, Nakanishi T, Suda T. Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells. Blood, 115: (e)1-9, 2010.

Iwasaki H, Arai F, Kubota Y, Suda T. Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver. Blood, 116: 544-553, 2010.

Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Hembree M, Yin T, Nakamura N, Gomei Y, Takubo K, Shiama H, Matsuoka S, Li L, Suda T. Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow. Cell Stem Cell, 6: 194-8, 2010.

Hosokawa K, Arai F, Yoshihara H, Iwasaki H, Nakamura Y, Gomei Y, Suda T. Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells. Blood, 116: 554-563, 2010.

Nakamura Y, Arai F, Iwasaki H, Hosokawa K, Kobayashi I, Gomei Y, Matsumoto Y, Yoshihara H, Suda T. Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells. Blood 116: 1422-1432, 2010.

Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M, Suda T. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell, 7: 391-402, 2010.

Kurihara T, Kubota Y, Ozawa Y, Ta kubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H. von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina. Development, 137: 1563-1571, 2010.

Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T. The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone hemostasis. J Exp Med, 207: 751-762, 2010.

Murakata A, Tanaka S, Mogushi K, Yasen M, Noguchi N, Irie T, Kudo A, Nakamura N, Tanaka H, Arii S. Gene expression signature of the gross morphology in hepatocellular carcinoma. Annals of Surgery, in press.

Tanaka S, Mogushi K, Yasen M, Noguchi N, Kudo A, Nakamura N, Ito K, Miki Y, Inazawa J, Tanaka H, Arii S. Gene expression phenotypes for vascular invasiveness of hepatocellular carcinomas. Surgery, 147(3): 405-414, 2010.

Aihara A, Tanaka S, Yasen M, Matsumura S, Mitsunori Y, Murakata A, Noguchi N, Kudo A, Nakamura N, Ito K, Arii S. The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma. Journal of Hepatology, 52(1): 63-71, 2010.

Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I, Inazawa J. miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis, 31(5): 766-76, 2010.

Uchida U, Tanaka S, Aihara A, Adikrisna R, Yoshitake K, Matsumura S, Mitsunori Y, Murakata A, Noguchi N, Irie K, Kudo A, Nakamura N, Lai PB, Arii S. Analogy between sphere forming ability and stemness of human hepatoma cells. Oncology Reports, 24: 1147-51, 2010.

Haraguchi N, Ishii H, Mimori K, Tanaka F, Ohkuma M, Kim HM, Akita H, Takiuchi D, Hatano H, Nagano H, Barnard GF, Doki Y, Mori M. CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest, 120(9): 3326-3339, 2010.

Miyoshi N, Ishii H, Nagai K, Hoshino H, Mimori K, Tanaka F, Nagano H, Sekimoto M, Doki Y, Mori M. Defined factors induce reprogramming of gastrointestinal cancer cells. Proc Natl Acad Sci USA, 107(1): 40-45, 2010.

Aikawa Y, Katsumoto T, Zhang P, Shima H, Shino M, Terui K, Ito E, Ohno H, Stanley ER, Singh H, Tenen DG, Kitabayashi I. PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2. Nat Med, 16(5): 580-585, 2010.

Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML. A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer Cell, 17(2): 198-212, 2010.

Tabu K, Kimura T, Sasai K, Wang L, Bizen N, Nishihara H, Taga T, Tanaka S. Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks. Mol Cancer, 9: 39-53, 2010.

Hinohara K, Gotoh N. Inflammatory signaling pathways in self-renewing breast cancer stem cells. Curr Opin Pharmacol, in press.

Sato T, Shimazaki T, Naka H, Fukami S, Okano H, Lax I, Schlessinger J, Gotoh N. FGF-FRS2a-Erk axis controls a self-renewal target Hes1 and growth of neural stem/progenitor cells. Stem Cells, in press.

Kojima K, Yamaguchi R, Imoto S, Yamauchi M, Nagasaki M, Yoshida R, Shimamura T, Ueno K, Higuchi T, Gotoh N, Miyano S. A state space representation of VAR models with sparse learning for dynamic gene networks. Genome Inform, 22: 56-68, 2010.

Iejima D, Minegichi Y, Takenaka K, Siswanto A, Watanabe M, Huang L, Watanabe T, Tanaka F, Kuroda M, Gotoh N. FRS2b, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor for EGF receptor family members via ERK binding. Oncogene, 29: 3087-3099, 2010.

Murohashi M, Hinohara K, Kuroda M, Isagawa T, Tsuji S, Kobayashi S, Umezawa K, Tojo A, Aburatani H, Gotoh N. Gene set enrichment analysis provides insight into novel signaling pathways in breast cancer stem cells. British J Cancer, 102: 206-212, 2010.

Murohashi M, Nakamura T, Tanaka S, Ichise T, Yoshida N, Yamamoto T, Shibuya M, Schlessinger J, Gotoh N. An FGF4-FRS2a-Cdx2 axis-in trophoblast stem cells induces BMP4 to regulate proper growth of early mouse embryos. Stem Cells, 28: 113-121, 2010.

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